FPGEE exam

Cigarette smoke causes an increase in levels of CYP1A isozymes. Theophylline is primarily metabolized by the CYP1A system. What would happen to theophylline clearance for an asthmatic patient in hospital who could not smoke?A . No changeB . IncreaseC . DecreaseView AnswerAnswer: C

What would be the preferred route of metabolism of succinyl choline?A . Ester hydrolysisB . N-oxidationC . Glucuronide conjugationD . A & BE . All of the aboveView AnswerAnswer: C

Which of the following is considered a class IA Sodium Channel blocker?A . PropafenoneB . DisopyramideC . AminodaroneD . QuinidineView AnswerAnswer: A

Mechanism of action of zalcitabine is:A . Inhibits inosine monophosphate dehydrogenaseB . Inhibits reverse transcriptaseC . Inhibits DNA gyraseD . Inhibits viral proteaseE . Inhibits dihydropteroate synthetaseView AnswerAnswer: B

Interactions with other drugs of tramadol is?A . beta-lactam antibiotics - synergismB . Rifampin: stimulates metabolismC . Phenytoin: stimulates metabolismD . MAO inhibitors: increase hyperpyrexia, excitation, delirium, seizures.E . Antihistamines: enhance analgesiaView AnswerAnswer: E

In a zero order elimination process, which of the following is true?A . The removal of drug is independent of drug concentrationB . Cl = Elimination rate/CpC . t1/2 = .7VD/ClD . All are trueView AnswerAnswer: A

Mechanism of resistance of sufentanil is:A . Penicillin binding proteins (PBPs)B . Decreased drug uptake by bacteriaC . Transport protein mutationsD . ToleranceE . Mutation of viral DNA polymeraseView AnswerAnswer: D

Subclass of lomafloxacin is:A . FluoroquinolonesB . IAC . CalciferolsD . Beta-lactamase resistant penicillinsE . Aldosterone antagonistsView AnswerAnswer: A

Indication of doxycycline is:A . Bacteroides (other than Bacteroides fragilis)B . AsthmaC . Meniere's diseaseD . Water intoxicationE . Broad spectrum antibacterial agentView AnswerAnswer: E

Mechanism of action of cefoxitin is:A . monoamine reuptake inhibitorB . Inhibits cholesterol synthesisC . Inhibits activation of GPIIb/IIIaD . Inhibits transpeptidaseE . Inhibits Na-K-2Cl transporterView AnswerAnswer: D