Interactions with other drugs of tramadol is?

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Interactions with other drugs of tramadol is?
A . beta-lactam antibiotics – synergism
B . Rifampin: stimulates metabolism
C . Phenytoin: stimulates metabolism
D . MAO inhibitors: increase hyperpyrexia, excitation, delirium, seizures.
E . Antihistamines: enhance analgesia

Answer: E

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